A regular on Channel 4 panel show 8 Out of 10 Cats, Manford started his comedy career by winning the North West comedian of the year title in 1999. A year later, he won the Leicester Mercury comedian of the year, and was a finalist in the So You Think You're Funny? new act competition.
He made his Edinburgh Fringe debut in 2005 with Urban Legend, a show that was nominated for the main Perrier award. The following year he won the Chortle award for best breakthrough act.