The following year he was chosen to take part in the well-regarded Comedy Zone showcase at Edinburgh, and also made the finals of the Daily Telegraph Open Mic award. His solo Edinburgh debut, Andy Zaltzman versus The Dog Of Doom, was nominated for the Perrier Best Newcomer award in 2001.
Zaltzman has worked extensively with John Oliver. In 2004, they launched a satire night in London and Edinburgh, called Political Animal, which transferred to Radio 4, and since 2007 have hosted The Bugle, a topical podcast for Times Online. They also wrote and starred in three series of The Department, again for Radio 4.
He performed at the Melbourne International Comedy Festival for the first time in April 2007, where he won the coveted Piece of Wood Award for the comedians' comedian.
Zaltzman has also written for several series of Bremner, Bird and Fortune, and in November 2008 his first book, entitled Does Anything Eat Bankers? And 53 Other Indispensable Questions For The Credit Crunched, was published.