The first series was hosted by Rob Rouse, but this time around each of the six episodes will have a different host.
A BBC spokesman said: ‘Each will bring their own unique vibe to the show and help to put together the week's line-up.’
The comics lined up to front the programme include Frankie Boyle, Brendon Burns, Mark Watson, Lucy Montgomery and Adam Buxton.
And acts contributing material, which will also go online, include Andrew Lawrence, Pappy’s Fun Club, Colin and Fergus, Katy Wix and Anna Crilly, Jon Richardson and Katherine Jakeways.
The shows will be recorded in November and December, and free audience tickets to the tapings are available from Standing Room Only on 020 8684 3333.
