Born in Perth, Western Australia, Jim Jeffries trained as an opera singer before turning to stand-up. He has appeared in festivals across the world as well as TV stand-up shows. In 2007, he was punched on stage at the Manchester Comedy Store, and the video of the incident became a worldwide hit o the internet.

He supported Dennis Leary at the new York comedy festival the same year; and the following year landed a pilot sitcom with Paramount Comedy. He was nominated for best headliner in the 2008 Chortle awards.